BIOGRAPHICAL SKETCH

NAME: Davide M.
LASTNAME: Donati
DATE OF BIRTH: July 16th, 1958
POSITION TITLE: Appointed Researcher in Orthopaedics, University of Bologna, Italy
Consultant in Orthopaedic Oncology surgery, Rizzoli Institute, Bologna, Italy

EDUCATION AND TRAINING:
INSTITUTION AND LOCATION        DEGREE        YEAR(s)
School of Medicine, Bologna, Italy        M.D.        1983
Massachusetts General Hospital, Boston, USA        Research Fellow        1986
Mayo clinic, Rochester, USA        Research Fellow        1987
Rizzoli Institute, Bologna , Italy        Orthopaedic Specialist        1988

PROFESSIONAL RECOGNITIONS:
•        Chief of the Laboratory of Bone Tissue regeneration associated to the Transplants and bone allograft in the Department
of Musculoskeletal Oncology

GRANTS:
•        Ricerca Finalizzata Ministero della Sanità 1998.

SELECTED BOOK CHAPTERS:
1.        Campanacci D.A., Caldora P., Beltrami G., Glukert B. Donati D., Capanna R. Osteoarticular allograft and megaprosthesis
reconstruction in bone tumor surgery In: G.O. Phillips ,Advances in Tissue Banking N°3; Agosto 1999, World Scientific, Hong
Kong; pag 67-85
2.        Donati D., Tella G., Gozzi E., Giacomini S., Mercuri M The use of allograft prosthetic composite (APC) in the proximal tibia
after  bone tumor resection. In G.O. Phillips , Advances in Tissue Banking N°4, Agosto 2000, World Scientific, Hong Kong, pag
313-324
Selected PEER REVIEWED PAPERS:
1.        R. Capanna, S. Boriani, Ch. Mabit, D. Donati, R. Savini Osteoid Osteoma of the spine: experience of the Rizzoli Institute
Journal of Orthopaedic Surgery Vol 6, N°1, 24-29, 1992
2.        D. Donati, R. D'Arenzo, C. Ercolani, S. Boriani Infection in limb salvage surgery for bone tumors Eur J Orthop Surg
Traumatol (1995) 5: 71-74
3.        Bertoni F., Bacchini P., Donati D., Martini A., Picci P., Campanacci M. Osteoblastoma like osteosarcoma: the Rizzoli
Institute experience Mod. Pathol. 6, 707-16, 1993
4.        Y. Salphale, D. Donati  Bone allografts – The present scenario Orthopaedic Update (India) 1998, Vol. 8, No. 3, pag 250-
254
5.        G.F.Zinghi, S.Boriani, L.Specchia, D.Donati, G.Galli, C.Mabit Les fractures de l'extremité inferieure de l'humerus chez
l'adulte Acta Orthop. Bel. 53-4, 446-456, 1987
6.        Capanna R., Boriani S., Mabit C.H., Donati D., Savini R. L'osteome osteoide de localisation rachidienne. Experience de
l'Institute Rizzoli. Revue de Chirurgie Orthopedique 1991, 77, 545-550.
7.        M. Mercuri, R. Capanna, M. Manfrini, G. Bacci, P. Picci, P. Ruggieri, A. Ferruzzi, A. Ferraro, D. Donati, R. Biagini, M.
DeMaio, A. Cazzola, M. Campanacci The management of malignant bone tumors in children and adolescent Clin. Orthop. and Rel.
Res., Vol. 264, 156-168, 1991
8.        Boriani S., Capanna R., Donati D., Levine A., Picci P., Savini R.: Osteoblastoma of the Spine  Clin. Orthop. 278, 37-45,
May 1992
9.        Levine, S. Boriani, D. Donati, M Campanacci Benign Tumors of the Cervical Spine Spine, Vol 17, (10S); 339-406, 1992
10.        R. Capanna, D.Donati, C.Masetti, M.Manfrini, A.Panozzo, R. Cadossi, M.Campanacci Effect of electromagnetic fields on
patients undergoing massive bone graft following bone tumor resection: a double blind study Clin. Orthop. 306, 213 - 221, 1994
11.        Bacci G., Picci P., Ferrari S., Mercuri M., Briccoli A., Donati D., Manfrini M., Zanoni A., Forni C., Campanacci M.
Synchronous multifocal osteosarcoma: results in twelve patients treated with neoadjuvant chemotherpy and siultaneous
resection of all the involved bones Annals of Oncology Oct 7 (8): 864-866, 1996
12.        Bacci G., Mercuri M., Briccoli A., Ferrari S., Bertoni F., Donati D., Monti C., Zanoni A., Forni C., Manfrini M. Osteogenic
Sarcoma of the Extremity with Detectable Lung Metastases at Presentation. Results of treatment of 23 patients with
chemotherapy followed by simultaneous resection of primary and metastatic lesions Cancer Vol 79 (2)  January 15, 1997: 245-
254
13.        D. Donati, R. Biscaglia The use of antibiotic-impregnated cement in infected reconstructions after resection for bone
tumors J.B.J.S Vol. 80 B, N°6, 1045-1050, 1998
14.        D. Donati, S.A. Bini, G. Bacci, M. Campanacci Follow-up protocols in orthopaedic oncology Tumori, 84: 57-59, 1998
15.        G. Bacci, S. Ferrari, D. Donati, A Longhi, F Bertoni, M Di Fiore, A. Comandone, M. Cesari, M. Campanacci  Neoadjuvant
chemotherapy for osteosarcoma of the extremity in patients in the fourth and fifth decade of life  Oncology Reports 5: 1259-
1263, 1988
16.        S. Ferrari, M. Mercuri, P. Picci, F. Bertoni, A. Brach del Prevert, A. Tienghi, A. Mancini, A. Longhi, S. Rimondini, D.
Donati, M. Manfrini, P. Ruggieri, R. Biagini, G. Bacci. Nonmetastatic osteosarcoma of the extremity: results of a neoadjuvant
chemotherapy protocol (IOR/OS-3) with high dose methotrexate, intraarterial or intravenous cisplatin, doxorubicin, and salvage
chemotherapy based on histologic tumor responce Tumori, Vol 85 (6), Nov 1999:458-464
17.        Lucarelli E, Sangiorgi L, Benassi S, Donati D, Gobbi GA, Picci P, Vacca A, Ribatti D Angiogenesis in lipoma: an
experimental study in the chick embryo chorioallantoic membrane Int J Mol Med Dec;4(6): 593-6; 1999
18.        G. Bacci, S. Ferrari, F. Bertoni, S. Rimondini, A. Longhi, P. Bacchini, C. Forni, M. Manfrini, D.Donati, P. Picci Prognostic
Factors in Non metastatic Ewing’s Sarcoma of Bone Treated With Adjuvant Chemotherapy: Analysis of 359 Patients at the
Istituto Ortopedico Rizzoli Journal of Clinical Oncology, Vol. 18, No. 1,; 4-11; 2000
19.        Bacci G, Briccoli A, Ferrari S, Saeter G, Donati D, Longhi A, Manfrini M, Bertoni F,      Rimondini S, Monti C, Forni C
Neoadjuvant chemotherapy for osteosarcoma of the extremities with synchronous lung metastasis treatment with cisplatin,
adriamycin and high dose methotrexate and ifosfamide Oncol rep. 7(2):339-46, 2000
20.        Bacci G, Ferrari S, Bertoni F, Donati D, Bacchini P, Longhi A, Brach del Prevert A, Forni C, Rimondini S Neoadjuvant
chemotherapy for peripheral malignant neuroectodermal tumor of bone: recent experience at  the istituto rizzoli J Clin Oncol 18
(4):885-92; 2000
21.        D. Donati, M. DiLiddo, M. Zavatta, M. Manfrini, G. Bacci, P. Picci, R. Capanna, M. Mercuri Massive bone allograft
reconstruction in  high-grade osteosarcoma. Clin Orthop Aug;(377):186-94, 2000
22.        Benedetti MG, Catani F, Donati D, Simoncini L Giannini S Muscle performance about the knee joint in patients who had
distal femoral replacement after resection of a bone tumor: an objective study with use of gait analysis JBJS 82A 11, Nov 2000:
1619-1625
23.        G. Bacci, S Ferrari, F. Bertoni, P. Picci, P. Bacchini, A. Longhi, D Donati, C Forni, L. Campanacci, M Campanacci  
Histologic response of high grade nonmetastatic osteosarcoma of the extremity to chemotherapy Clin Orthop and Rel Res 386,
186-196, 2001
24.        Longhi A., Fabbri N., Donati D., Capanna R., Briccoli A., Biagini R., Bernini G., Ferrari S., Versari M. Bacci G.
Neoadjuvant chemotherapy for patients with syncronous multifocal osteosarcoma: result in 11 cases J of Chemotherapy 13, N°
3: 326-332,2001
25.        Bacci G., Briccoli A., Ferrari S., Longhi A., Mercuri M., Capanna R., Donati D., Lari S., Forni C., De Paolis M. Neoadjuvant
chemotherapy for osteosarcoma of the extremity: long-term results of the Rizzoli 4th protocol Eur. Journal of Cancer, Nov 37
(16):2030-9 2001
26.        D. Donati, M. Zavatta, E. Gozzi, S. Giacomini, L. Campanacci, M. Mercuri Modular prosthetic replacement of the proximal
femur after resection of a bone tumor: a long term follow-up. Journal of Bone and Joint Surg. 83-(B): 1156-60 Dicembre 2001
27.        Bacci G., Longhi A., Ferrari S., Lari S., Manfrini M., Donati D., Forni C., Versari M. Prognostic significance of serum
alkaline phosphatase in osteosarcoma of the extremity  treated with neoadjuvant chemotherapy: recent experience at Rizzoli
Institute Oncology Reports 9: 171-175, 2002
28.        D. Donati, E. Gozzi, S. Giacomini, M. Mercuri Proximal femur reconstrucion by an Allograft Prosthesis Composite (APC).
Clin Orthop and Rel Res  (394), 192-200 2002
29.        D. Donati, S. Giacomini, E. Gozzi, E. Sorin, T.S. Borz, M. Mercuri, G. Bacci Knee arthrodesis with temporary spacer
performed in malignant tumor around the knee Arch Orthop and Trauma Surg (March 2002) 122:123-128
30.        G. Bacci, S. Ferrari, S. Lari, M. Mercuri, D. Donati, A. Longhi, C. Forni, F. Bertoni, M. Versari, E. Pignotti Osteosarcoma
of the limb: Amputation or limb salvage in patients treated by neoadjuvant chemotherapy JBJS (B)  vol 84- B 88-92, January
2002
31.        D. Donati, S. Giacomini, E. Gozzi, E. Sorin, Y. Salphale, M. Mercuri, and  HJ Mankin, DS Springfield, MC Gebhardt
Allograft arthrodesis in the treatment of bone tumors: a two center study Clin Orthop and Rel Res 400, 217-224, July 2002
32.        G. Bacci, S. Ferrari, A. Longhi, P. Picci, M. Mercuri, T.A. Alvegard, G. Saeter, D. Donati, M. Manfrini, S. Lari, A. Briccoli,
C. Forni High dose ifosfamide in combination with high dose methotrexate, adriamycin and Cisplatin in the neoadjuvant
treatment of extremity osteosarcoma: preliminary result of an italian sarcoma group/scandinavian sarcoma group pilot study J.
of Chemotherapy Vol 14 n2 (198-206): 2002
33.        G. Gobbi, L. Sangiorgi, L. Lenzi, R. Casadei, S. Canaider, P. Strippoli, E. Lucarelli, I Ghedini, D. Donati, N. Fabbri, J
Warzecha, C. Yeoung, P. Picci P. Carinci Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cells
Int Journal of Oncology 20: 143-147, 2002
34.        G. Bacci, M. Mercuri, A. Longhi, F. Bertoni, E. Barbieri, D. Donati, S. Giacomini, P. Bacchini, E. Pignotti, C. Forni, S.
Ferrari Neoadjuvant chemotherapy for Ewing’s tumour of bone: recent experience at the Rizzoli Orthopaedic Institute Eur.
Journal of Cancer 2002 Nov;38(17): 2243-51
35.        G. Bacci, S. Ferrari, A. Longhi, M. Versari, C. Forni, D. Donati, P. Trentani, E. Barbieri Local and systemic control in
Ewing’s sarcoma of femur treated with chemotherapy, and locally by radiotherapy and/or surgery J Bone Joint Surg Br 2003 Jan;
85(1):107-14
36.        Bacci G, Ferrari S, Mercuri M, Longhi A, Giacomini S, Forni C, Bertoni F, Manfrini M, Barbieri E, Lari S, Donati D.
Multimodal therapy for the treatment of nonmetastatic Ewing sarcoma of the pelvis. J Pediatr Hematol Oncol 2003 Feb;25(2):
118-24
37.        Lucarelli E, Beccheroni A, Donati D, Sangiorgi L , Cenacchi A, Del Vento AM, Meotti C, Zambon Bertoja A, Giardino R,
Fornasari PM, Mercuri M and Picci P. Platelet-derived growth factors enhance proliferation of human stromal stem cells.
Biomaterials  24 (2003) 3095-3100
38.        Beccheroni A, Lucarelli E, Donati D, Sangiorgi L , Caponcelli S, Gorini M, Zambon Bertoja A, Giardino R, Mercuri M,
Ferrari S, Bacci G and Picci P. Recovery of stromal stem cells in bone sarcomas patients after chemotherapy: implication for cell-
based therapy in bone defect reduction. Oncology Reports 10: 891-896,2003
39.        Aflatoon K, Bertoni F, Donati D, Staals EL, Mercuri M, Frassica FJ. Scapular soft tissue mass. Clin Orthop. 2003 Sep;
(414):336-41.
40.        Bacci G, Forni C, Ferrari S, Longhi A, Bertoni F, Mercuri M, Donati D, Capanna R, Bernini G, Briccoli A, Setola E, Versari
M. Neoadjuvant chemotherapy for osteosarcoma of the extremity: intensification of preoperative treatment does not increase
the rate of good histologic response to the primary tumor or improve the final outcome. J Pediatr Hematol Oncol. 2003 Nov; 25
(11): 845-53.
41.        Bacci G, Ferrari S, Longhi A, Donati D, De Paolis M, Forni C, Versari M, Setola E, Briccoli A, Barbieri E. Therapy and
survival after recurrence of Ewing's tumors: the Rizzoli experience in 195 patients treated with adjuvant and neoadjuvant
chemotherapy from 1979 to 1997. Ann Oncol. 2003 Nov; 14(11): 1654-9.
42.        Bacci G, Ferrari S, Longhi A, Donati D, Manfrini M, Giacomini S, Briccoli A, Forni C, Galletti S. Nonmetastatic
osteosarcoma of the extremity with pathologic fracture at presentation: local and systemic control by amputation or limb
salvage after preoperative chemotherapy. Acta Orthop Scand. 2003 Aug; 74(4): 449-54.
43.        Bacci G, Briccoli A, Rocca M, Ferrari S, Donati D, Longhi A, Bertoni F, Bacchini P, Giacomini S, Forni C, Manfrini M,
Galletti S. Neoadjuvant chemotherapy for osteosarcoma of the extremities with metastases at presentation: recent experience
at the Rizzoli Institute in 57 patients treatedwith cisplatin, doxorubicin, and a high dose of methotrexate and ifosfamide. Ann
Oncol. 2003 Jul; 14(7): 1126-34.
44.        Bacci G, Bertoni F, Longhi A, Ferrari S, Forni C, Biagini R, Bacchini P, Donati D, Manfrini M, Bernini G, Lari S.
Neoadjuvant chemotherapy for high-grade central osteosarcoma of the extremity. Histologic response to preoperative
chemotherapy correlates with histologic subtype of the tumor. Cancer. 2003 Jun 15; 97(12): 3068-75.
45.        Bacci G, Forni C, Longhi A, Ferrari S, Donati D, De Paolis M, Barbieri E, Pignotti E, Rosito P, Versari M. Long-term
outcome for patients with non-metastatic Ewing's sarcoma treated with adjuvant and neoadjuvant chemotherapies. 402
patients treated at Rizzoli between 1972 and 1992. Eur J Cancer. 2004 Jan; 40(1): 73-83.
46.        Bacci G, Ferrari S, Longhi A, Donati D, Barbieri E, Forni C, Bertoni F, Manfrini M, Giacomini S, Bacchini P.  Role of
surgery in local treatment of Ewing's sarcoma of the extremities in patients undergoing adjuvant and neoadjuvant
chemotherapy. Oncol Rep. 2004 Jan; 11(1): 111-20.
47.        D. Donati, S Giacomini, E. Gozzi, S. Ferrari, L. Sangiorgi, A Tienghi, H DeGroot, F. Bretoni, P. Bacchini, G. Bacci, M.
Mercuri Osteosarcoma of the pelvis Eur J Surg Oncol. 2004 Apr;30(3):332-40.
48.        Lucarelli E, Donati D, Cenacchi A, Fornasari PM. Bone reconstruction of large defects using bone marrow derived
autologous stem cells. Transfus Apheresis Sci. 2004 Apr;30(2):169-74.
Dr. Donati's research
Dr. Donati serves on the Scientific and Medical Advisory Board of the MHE Research Foundation
Orthopaedic & Research papers authored by Dr. Donati
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