Dr. Esko serves on the Scientific and Medical Advisory Board of the MHE Research Foundation and was past
president of the
Society of Glycobiology
Research authored by Dr. Esko
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List of Publications via PubMed
(NIH National Library of Medicine)
Jeffrey D. Esko Ph.D. research
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ChangeDetection
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Wings of HOPE as we REACH
for the CURE to
Multiple Hereditary Exostoses Syndrome
Multiple Osteochondroma Syndrome
Jeffrey D. Esko, Ph.D.
Professor, Department of Cellular and Molecular Medicine
Co-Director, Glycobiology Research & Training Center
University of California, San Diego, School of Medicine
Esko lab website page

Research in Dr. Esko’s laboratory focuses on the structure, biosynthesis, and function of proteoglycans. Current work includes
structural studies of heparan sulfate by mass spectrometry; studies of 3-O-sulfation of heparan sulfate; application of genome-
wide methods to identify novel genes involved in heparan sulfate assembly; analysis of guanidinylated glycosides that bind to
proteoglycans and facilitate delivery of high molecular weight cargo into the interior of the cell; studies of proteoglycans in
lipoprotein metabolism; and studies on the role of proteoglycans in inflammation. His lab has extensive experience in the
isolation and characterization of glycosaminoglycans, selection and characterization of mutant cell lines altered in
glycosaminoglycan metabolism, and development of genetic models altered in glycosaminoglycan metabolism in mice.

Several studies in his lab focus specifically on Hereditary Multiple Exostoses. Early on his group characterized heparan sulfate-
deficient cell lines and demonstrated genetically that alteration of Ext1 affected the copolymerization of heparan sulfate in vivo
and in vitro. He also mapped the glucuronosyltransferase domain in Ext1. His group characterized Ext1 and Ext2 deficient mice,
and were the first group to demonstrate that the animals develop exostoses on the ribs. Subsequent studies have shown that
the formation of exostoses exhibits gene dosage effects and that the exostoses originate from cells of the chondrocyte
lineage. Ongoing work is focused on developing therapeutic approaches for treating the disease. Dr. Esko is one of The MHE
Research Foundation members of the Scientific and Medical  Board A co-chaired the first conference sponsored by the MHE
Research Foundation, and will organize and chair the next meeting in 2015.  












































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