|Multiple Hereditary Exostoses: Insights Into Pathogensis
Was held November 3–5, 2005
|Composition of Organizing Committee
Dan Wells, Ph.D., Professor at the University of Houston
Dr. Wells is the former Chair of the Department of Biology and Biochemistry and the director of a NSF funded summer research program. He is
currently President of the UH Sigma Xi Chapter and serves as a Scientific.
He has helped organized multiple small meetings and symposia. Over the past fifteen years, Dr. Wells has 30 publications relevant to HME.
Among his accomplishments in the HME field, Dr. Wells, together with Dr. Hecht, was the first to genetically map the EXT1 gene to 8q24.1. In
addition, he positionally cloned and subsequently analyzed the EXT1 gene and developed the first knock-out mouse model for HME. Dr. Wells’
current research is aimed at understanding the molecular signaling involved in the etiology of HME.
Jacqueline Hecht, Ph.D., Professor at the University of Texas-Houston Medical School
Dr. Hecht is the Director of the Genetic Counseling Program, Department of Pediatrics, Division of Medical Genetics. She is a Ph.D. medical
geneticist who provides clinical diagnostic expertise for all types of birth defects and specializes in skeletal dysplasias and HME. Her research
has focused on identifying the molecular causes of HME and the effect of EXT mutations on the development of the exostoses. She has a
strong interest in cartilage biology and studied the expression of cartilage-specific genes in the exostoses.
Sarah Ziegler, National Director and Coordinator of Research, Executive Director of the National MHE Registry.
Ms. Ziegler has been the driving force in developing a growing network of MHE researchers and clinicians that has resulted in several successful
collaborations. She has been very involved in organizing researchers and physicians interested in the EXT gene, heparan sulfate formation,
and developmental biology. Under the auspices of the National MHE registry samples of exostoses and other reagents are being studied in
several laboratories to understand the etiology of the disease and potential mechanisms for controlling the growth of the exostoses.
Ms. Ziegler has collaborated with researchers, developing questionnaire studies and obtaining participants from its membership. Studies include
“Hereditary Multiple Exostoses and Pain: To what extent is pain associated with HME?” with the Jacqueline T. Hecht, Ph.D., University of Texas
Houston Medical Center, the results of which indicated that pain in HME has been under-appreciated and must be addressed in the medical care
of HME patients and with Yu Yamaguchi, M.D., Ph.D. of the Burnham Institute on “The Possible Relationship of Heparan Sulfate and Nerve Cell
Function to Neurological Clinical Symptoms in patients with Multiple Hereditary Exostoses.”
|Conference participants 2005
|Everything you need to know about Multiple Hereditary Exostoses workshop.
|[Photo courtesy of University of Texas Houston Medical Center taken during the 2005 conference]
Top Row, Left to Right: Henry Kronenberg, M.D., Ben Alman, M.D., Matthew Hilton, Ph.D., Dan Wells, Ph.D., Wim Wuyts, Ph.D.,
Luca Sangiorgi, M.D., Ph.D., Yoshihiro Matsumoto, M.D., Rahul Warrior, Ph.D., Jeff Esko, Ph.D.
Middle Row, Left to Right: T. Michael Underhill, Ph.D., Pancras Hogendoorn, M.D., Ph.D., David Ornitz,M.D., Ph.D., Brett Casey, M.D.,
Andrea Vortkamp, Ph.D., Marion Kusche-Gullberg, Ph.D., Catherine Merry, Ph.D., Malgorzata Wiweger, Ph.D., Melissa Rusch, Maurizio Pacifici, Ph.D., John Hassell, Ph.D.,Mohammad
Shahnazari, Ph.D., Craig Eaton, Esq.,Jeremy Turnbull, Ph.D.
Bottom Row, Left to Right: Dominique Stickens, Ph.D., Sarah Ziegler, Christine Alvarez, M.D., Jacqueline Hecht, Ph.D.,George Thomson, M.D.,
Scott Selleck, M.D., Ph.D., Yu Yamaguchi, M.D., Ph.D.
Not Pictured: John E. Herzenberg, M.D., Harish S. Hosalkar, M.D., Ashish Sinha, M.D., Ph.D., Sandra Darilek, M.S.
|2005 MHE Research Conference
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